The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies.

doi:10.1016/j.cell.2021.06.002

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The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies.

Cell - 22 Jul 2021

Copin Richard, Baum Alina, Wloga Elzbieta, Pascal Kristen E, Giordano Stephanie, Fulton Benjamin O, Zhou Anbo, Negron Nicole, Lanza Kathryn, Chan Newton, Coppola Angel, Chiu Joyce, Ni Min, Wei Yi, Atwal Gurinder S, Hernandez Annabel Romero, Saotome Kei, Zhou Yi, Franklin Matthew C, Hooper Andrea T, McCarthy Shane, Hamon Sara, Hamilton Jennifer D, Staples Hilary M, Alfson Kendra, Carrion Ricardo, Ali Shazia, Norton Thomas, Somersan-Karakaya Selin, Sivapalasingam Sumathi, Herman Gary A, Weinreich David M, Lipsich Leah, Stahl Neil, Murphy Andrew J, Yancopoulos George D, Kyratsous Christos A

Abstract excerpt

Monoclonal antibodies against SARS-CoV-2 are a clinically validated therapeutic option against COVID-19. Because rapidly emerging virus mutants are becoming the next major concern in the fight against the global pandemic, it is imperative that these therapeutic treatments provide coverage against circulating variants and do not contribute to development of treatment-induced emergent resistance. To this end, we...

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Identifiers

PMID: 34161776
DOI: 10.1016/j.cell.2021.06.002
PMCID: PMC8179113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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