Article
Insight on Mutation-Induced Resistance from Molecular Dynamics Simulations of the Native and Mutated CSF-1R and KIT.
PloS one - 1 Jan 2016
Da Silva Figueiredo Celestino Gomes Priscila, Chauvot De Beauchêne Isaure, Panel Nicolas, Lopez Sophie, De Sepulveda Paulo, Geraldo Pascutti Pedro, Solary Eric, Tchertanov Luba
Abstract excerpt
The receptors tyrosine kinases (RTKs) for the colony stimulating factor-1, CSF-1R, and for the stem cell factor, SCFR or KIT, are important mediators of signal transduction. The abnormal function of these receptors, promoted by gain-of-function mutations, leads to their constitutive activation, associated with cancer or other proliferative diseases. A secondary effect of the mutations is the alteration of...
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