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Article

Molecular basis of the constitutive activity and STI571 resistance of Asp816Val mutant KIT receptor tyrosine kinase.

Journal of molecular graphics & modelling - 1 Oct 2004

Foster Rowan, Griffith Renate, Ferrao Petranel, Ashman Leonie

Abstract excerpt

The receptor tyrosine kinase, KIT, displays activating mutations in the kinase domain, which are associated with various cancers. We have used homology modelling based on the crystal structures of the insulin receptor kinase in active and inactive conformations to predict the corresponding structures of the KIT kinase domain. We have prepared four KIT models, one each for the active and inactive conformations of...

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Source

Identifiers

PMID: 15363456
DOI: 10.1016/j.jmgm.2004.04.003

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular basis of the constitutive activity and STI571 resistance of Asp816Val mutant KIT receptor tyrosine kinase.PMID 15363456Read ↗

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A change in structural integrity of c-Kit mutant D816V causes constitutive signaling.Semantic proximity Read ↗

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Insight on Mutation-Induced Resistance from Molecular Dynamics Simulations of the Native and Mutated CSF-1R and KIT.Semantic proximity Read ↗

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Analysis of the activating mutations within the activation loop of leukemia targets Flt-3 and c-Kit based on protein homology modeling.Semantic proximity Read ↗

Are two better than one? A novel double-mutant KIT in GIST that responds to Imatinib.Semantic proximity Read ↗

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