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Article

Isolation of Cerebral Endothelial Cells from CCM1/KRIT1 Null Mouse Brain.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020

Nobiletti Nicholas, Glading Angela J

Abstract excerpt

Cerebral cavernous malformation (CCM) is driven by changes in the cerebral microvascular endothelial cell population. Mouse models of CCM have successfully recapitulated the disease in vivo; however, dissection of the disease pathogenesis and molecular mechanism is challenging in vivo due to limited access to the involved tissue in live animals. Therefore, in vitro tissue culture models are required. This...

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PMID: 32524558
DOI: 10.1007/978-1-0716-0640-7_19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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