Article
Isolation of Cerebral Endothelial Cells from CCM1/KRIT1 Null Mouse Brain.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020
Nobiletti Nicholas, Glading Angela J
Abstract excerpt
Cerebral cavernous malformation (CCM) is driven by changes in the cerebral microvascular endothelial cell population. Mouse models of CCM have successfully recapitulated the disease in vivo; however, dissection of the disease pathogenesis and molecular mechanism is challenging in vivo due to limi...
Topics
- Animals
- Blood-Brain Barrier
- Brain
- Cell Separation
- Disease Models, Animal
- Endothelial Cells
- Hemangioma, Cavernous, Central Nervous System
- KRIT1 Protein
- Mice
- Mice, Knockout
- Microtubule-Associated Proteins
- Mutation