Article
Novel Murine Models of Cerebral Cavernous Malformations.
Angiogenesis - 1 Nov 2020
Detter Matthew R, Shenkar Robert, Benavides Christian R, Neilson Catherine A, Moore Thomas, Lightle Rhonda, Hobson Nicholas, Shen Le, Cao Ying, Girard Romuald, Zhang Dongdong, Griffin Erin, Gallione Carol J, Awad Issam A, Marchuk Douglas A
Abstract excerpt
Cerebral cavernous malformations (CCMs) are ectatic capillary-venous malformations that develop in approximately 0.5% of the population. Patients with CCMs may develop headaches, focal neurologic deficits, seizures, and hemorrhages. While symptomatic CCMs, depending upon the anatomic location, can be surgically removed, there is currently no pharmaceutical therapy to treat CCMs. Several mouse models have been...
Topics
- 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
- Acute Disease
- Animals
- Apoptosis Regulatory Proteins
- Brain
- Cholecalciferol
- Chronic Disease
- Cyclic N-Oxides
- Disease Models, Animal
- Gene Deletion