Article
Impact of Driver Mutations on the Evolution of Isolated Metachronous Lung Metastasis of Pancreatic Ductal adenocarcinoma.
Molecular diagnosis & therapy - 1 Aug 2020
Vitellius Carole, Griveaux Océane, Morvant Benjamin, Pedrono Estelle, Venara Aurélien, Ingster Olivier, Baize Nathalie, Dincuff Eloise, Rousselet Marie-Christine, Guardiola Philippe, Caroli-Bosc François-Xavier
Abstract excerpt
BACKGROUND: The incidence of pancreatic ductal adenocarcinoma (PDAC) is increasing sharply. The survival of patients with metastases is usually about a year. However, the occurrence of isolated lung metastases after resection of the primary tumor, although rare, seems to indicate a better prognosis, with an average survival ranging from 40 to 80 months. KRAS, TP53, CDK2NA, and SMAD4 are the most common driver...
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