Article
Molecular characteristics of early-onset pancreatic ductal adenocarcinoma.
Molecular oncology - 1 Mar 2024
Debernardi Silvana, Liszka Lukasz, Ntala Chara, Steiger Katja, Esposito Irene, Carlotti Emanuela, Baker Ann-Marie, McDonald Stuart, Graham Trevor, Dmitrovic Branko, Feakins Roger M, Crnogorac-Jurcevic Tatjana
Abstract excerpt
The median age of patients with pancreatic ductal adenocarcinoma (PDAC) at diagnosis is 71 years; however, around 10% present with early-onset pancreatic cancer (EOPC), i.e., before age 50. The molecular mechanisms underlying such an early onset are unknown. We assessed the role of common PDAC drivers (KRAS, TP53, CDKN2A and SMAD4) and determined their mutational status and protein expression in 90...
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