Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An Extended Primer Grip of Picornavirus Polymerase Facilitates Sexual RNA Replication Mechanisms.

Journal of virology - 30 Jul 2020

Kempf Brian J, Watkins Colleen L, Peersen Olve B, Barton David J

Abstract excerpt

Picornaviruses have both asexual and sexual RNA replication mechanisms. Asexual RNA replication mechanisms involve one parental template, whereas sexual RNA replication mechanisms involve two or more parental templates. Because sexual RNA replication mechanisms counteract ribavirin-induced error catastrophe, we selected for ribavirin-resistant poliovirus to identify polymerase residues that facilitate sexual RNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Directed RNA Polymerases
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Picornaviridae

Share to Picornaviridae Infections

Share to Poliovirus

Share to Ribavirin

Share to RNA-Dependent RNA Polymerase

Source

Open in PubMed Open full text

Identifiers

PMID: 32522851
DOI: 10.1128/JVI.00835-20
PMCID: PMC7394906

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An Extended Primer Grip of Picornavirus Polymerase Facilitates Sexual RNA Replication Mechanisms.PMID 32522851Read ↗

Structure-Function Relationships Underlying the Replication Fidelity of Viral RNA-Dependent RNA PolymerasesSemantic proximity Read ↗

Thinking Outside the Triangle: Replication Fidelity of the Largest RNA VirusesSemantic proximity Read ↗

Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity.Semantic proximity Read ↗

The SARS-CoV nsp12 Polymerase Active Site Is Tuned for Large-Genome ReplicationSemantic proximity Read ↗

Slow PPi release enhances fidelity of the SARS-CoV-2 RNA dependent RNA polymerase.Semantic proximity Read ↗

Coronaviruses: An RNA proofreading machine regulates replication fidelity and diversitySemantic proximity Read ↗

Fidelity Variants and RNA Quasispecies.Semantic proximity Read ↗

Viral Polymerase-Helicase Complexes Regulate Replication Fidelity To Overcome Intracellular Nucleotide Depletion.Semantic proximity Read ↗

A template RNA entry channel in the fingers domain of the poliovirus polymerase.Semantic proximity Read ↗

Mutations in the Primer Grip Region of HIV Reverse Transcriptase Can Increase Replication FidelitySemantic proximity Read ↗

Characterization of SARS-CoV-2 replication complex elongation and proofreading activitySemantic proximity Read ↗

Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.