Genome-wide association study meta-analysis of neurofilament light (NfL) levels in blood reveals novel loci related to neurodegeneration.

doi:10.1038/s42003-024-06804-3

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Genome-wide association study meta-analysis of neurofilament light (NfL) levels in blood reveals novel loci related to neurodegeneration.

Communications biology - 9 Sept 2024

Ahmad Shahzad, Imtiaz Mohammad Aslam, Mishra Aniket, Wang Ruiqi, Herrera-Rivero Marisol, Bis Joshua C, Fornage Myriam, Roshchupkin Gennady, Hofer Edith, Logue Mark, Longstreth W T, Xia Rui, Bouteloup Vincent, Mosley Thomas, Launer Lenore J, Khalil Michael, Kuhle Jens, Rissman Robert A, Chene Genevieve, Dufouil Carole, Djoussé Luc, Lyons Michael J, Mukamal Kenneth J, Kremen William S, Franz Carol E, Schmidt Reinhold, Debette Stephanie, Breteler Monique M B, Berger Klaus, Yang Qiong, Seshadri Sudha, Aziz N Ahmad, Ghanbari Mohsen, Ikram M Arfan

Abstract excerpt

Neurofilament light chain (NfL) levels in circulation have been established as a sensitive biomarker of neuro-axonal damage across a range of neurodegenerative disorders. Elucidation of the genetic architecture of blood NfL levels could provide new insights into molecular mechanisms underlying neurodegenerative disorders. In this meta-analysis of genome-wide association studies (GWAS) of blood NfL levels from...

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PMID: 39251807
DOI: 10.1038/s42003-024-06804-3
PMCID: PMC11385583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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