Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Context-Dependent Gait Choice Elicited by EphA4 Mutation in Lbx1 Spinal Interneurons.

Neuron - 2 Mar 2016

Satoh Daisuke, Pudenz Christiane, Arber Silvia

Abstract excerpt

The most commonly used locomotor strategy in rodents is left-right limb alternation. Mutation of the axon guidance molecule EphA4 profoundly alters this basic locomotor pattern to synchrony. Here we report that conditional mutation of EphA4 in spinal interneurons expressing the transcription factor Lbx1 degrades the robustness in the expression of left-right alternating gait during development. Lbx1 EphA4...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholera Toxin
Share to Benzofurans
Share to Extremities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Functional Laterality

Share to Interneurons

Share to Quinolines

Share to Swimming

Source

Identifiers

PMID: 26924434
DOI: 10.1016/j.neuron.2016.01.033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Context-Dependent Gait Choice Elicited by EphA4 Mutation in Lbx1 Spinal Interneurons.PMID 26924434Read ↗

Change in the balance of excitatory and inhibitory midline fiber crossing as an explanation for the hopping phenotype in EphA4 knockout mice.Semantic proximity Read ↗

Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection.Semantic proximity Read ↗

Single-cell transcriptomic analysis unveils spinal motor neuron subtype diversity underpinning the water-to-land transition in vertebratesSemantic proximity Read ↗

Age- and speed-dependent modulation of gaits in DSCAM2J mutant mice.Semantic proximity Read ↗

Rebuilding Spinal Circuit Computation Through a Patient-Specific Interneuron Precision ModelSemantic proximity Read ↗

EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract.Semantic proximity Read ↗

Shared developmental gait disruptions across two mouse models of neurodevelopmental disordersSemantic proximity Read ↗

Spatial and network principles behind neural generation of locomotionSemantic proximity Read ↗

Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline.Semantic proximity Read ↗

An ancient role for Collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron developmentSemantic proximity Read ↗

Behavioral Characterization of dmrt3a Mutant Zebrafish Reveals Crucial Aspects of Vertebrate Locomotion through Phenotypes Related to Acceleration.Semantic proximity Read ↗

Environmental and molecular modulation of motor individuality in larval zebrafishSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.