Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation of rat Zp2 causes ROS-mediated oocyte apoptosis.

Reproduction (Cambridge, England) - 1 Sept 2020

Wang Yan, Huang Hualin, Zeng Minghua, Quan Ru-Ping, Yang Jun-Ting, Guo Dan, Sun Ying, Deng Hongwen, Xiao Hongmei

Abstract excerpt

In this study, we investigated a gene-edited (Zp2MT/MT) rat model of infertility caused by the failure to express the zona pellucida glycoprotein 2 (ZP2) due to the significant reduction of mRNA amount. We examined the defects in the zona pellucida (ZP) caused by ZP2 nullification and the influence of these defects on aspects of oocyte development, including apoptosis and fertilization ability. To investigate the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to Apoptosis
Share to Granulosa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oocytes

Share to Oogenesis

Share to Reactive Oxygen Species

Share to Signal Transduction

Source

Identifiers

PMID: 32520719
DOI: 10.1530/REP-20-0037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation of rat Zp2 causes ROS-mediated oocyte apoptosis.PMID 32520719Read ↗

Identification of zona pellucida defects revealed a novel loss-of-function mutation in ZP2 in humans and rats.Semantic proximity Read ↗

Mutant <i>Zp1</i> results in Zona Pellucida Lacking and Female Infertility in Rats and HumansSemantic proximity Read ↗

Dosage effects of ZP2 and ZP3 heterozygous mutations cause human infertility.Semantic proximity Read ↗

Gene knockouts that cause female infertility: search for novel contraceptive targets.Semantic proximity Read ↗

Zona Pellucida Genes and Proteins: Essential Players in Mammalian Oogenesis and FertilitySemantic proximity Read ↗

Heterozygous mutations in ZP1 and ZP3 cause formation disorder of ZP and female infertility in human.Semantic proximity Read ↗

ZP4 confers structural properties to the zona pellucida essential for embryo developmentSemantic proximity Read ↗

Defective zonae pellucidae in Zp2-null mice disrupt folliculogenesis, fertility and developmentSemantic proximity Read ↗

Cracking the egg: increased complexity in the zona pellucidaSemantic proximity Read ↗

Female fertility and the zona pellucidaSemantic proximity Read ↗

Novel Heterozygous Mutations in ZP2 Cause Abnormal Zona Pellucida and Female Infertility.Semantic proximity Read ↗

Oocyte-Specific Knockout: A Novel In Vivo Approach for Studying Gene Functions During Folliculogenesis, Oocyte Maturation, Fertilization, and Embryogenesis1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.