Article

Mutant <i>Zp1</i> results in Zona Pellucida Lacking and Female Infertility in Rats and Humans

2019-10-30

Abstract excerpt

Zona pellucida (ZP) plays a vital role in reproductive processes including oogenesis, fertilization and preimplantation development of embryo. The ZP of humans is composed of four glycoproteins (ZP1-ZP4), same as rats ZP. Our previous research reported a first case of human infertility due to ZP1 mutation, but the mechanism was unclear. Here we developed a genome editing in vivo rat model and a co-transfected i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 991cb542-2c56-5803-a34d-3040bfdf117e
DOI: 10.1101/825018

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mutant <i>Zp1</i> results in Zona Pellucida Lacking and Female Infertility in Rats and HumansDOI 10.1101/825018Read

Identification of zona pellucida defects revealed a novel loss-of-function mutation in ZP2 in humans and rats.Semantic proximity Read

Heterozygous mutations in ZP1 and ZP3 cause formation disorder of ZP and female infertility in human.Semantic proximity Read

[The human zona pellucida: New genetic findings].Semantic proximity Read

Dosage effects of ZP2 and ZP3 heterozygous mutations cause human infertility.Semantic proximity Read

Compound heterozygous ZP1 mutations cause empty follicle syndrome in infertile sistersSemantic proximity Read

Zona Pellucida Genes and Proteins: Essential Players in Mammalian Oogenesis and FertilitySemantic proximity Read

Mutant ZP1 in Familial InfertilitySemantic proximity Read

Compound heterozygous <i>ZP1</i> mutations cause empty follicle syndrome in infertile sistersSemantic proximity Read

Mutation of rat Zp2 causes ROS-mediated oocyte apoptosis.Semantic proximity Read

Gene knockouts that cause female infertility: search for novel contraceptive targets.Semantic proximity Read

A Novel Homozygous Nonsense Mutation in ZP1 Causes Female Infertility due to Empty Follicle Syndrome.Semantic proximity Read

A novel gene mutation in ZP3 loop region identified in patients with empty follicle syndrome.Semantic proximity Read