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Defective zonae pellucidae in Zp2-null mice disrupt folliculogenesis, fertility and development

1 Apr 2001

Abstract excerpt

All vertebrate eggs are surrounded by an extracellular matrix. This matrix is known as the zona pellucida in mammals and is critically important for the survival of growing oocytes, successful fertilization and the passage of early embryos through the oviduct. The mouse zona pellucida is composed of three glycoproteins (ZP1, ZP2 and ZP3), each encoded by a single copy gene. Using targeted mutagenesis in embryonic...

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PMID: 11245577
DOI: 10.1242/dev.128.7.1119

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