Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ZP4 confers structural properties to the zona pellucida essential for embryo development

21 Oct 2019

Abstract excerpt

Zona pellucida (ZP), the extracellular matrix sheltering mammalian oocytes and embryos, is composed by 3 to 4 proteins. The roles of the three proteins present in mice have been elucidated by KO models, but the function of the fourth component (ZP4), present in all other eutherian mammals studied so far, has remained elusive. Herein, we report that ZP4 ablation impairs fertility in female rabbits. Ovulation,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Renal and related cancers
Share to Reproductive Biology and Fertility
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31635692
DOI: 10.7554/elife.48904

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ZP4 confers structural properties to the zona pellucida essential for embryo developmentPMID 31635692Read ↗

New Insights into the Mammalian Egg Zona PellucidaSemantic proximity Read ↗

Zona Pellucida Genes and Proteins: Essential Players in Mammalian Oogenesis and FertilitySemantic proximity Read ↗

The mouse zona pellucida: folliculogenesis, fertility and pre-implantation development.Semantic proximity Read ↗

The mammalian zona pellucida: its biochemistry, immunochemistry, molecular biology, and developmental expressionSemantic proximity Read ↗

Defective zonae pellucidae in Zp2-null mice disrupt folliculogenesis, fertility and developmentSemantic proximity Read ↗

[The human zona pellucida: New genetic findings].Semantic proximity Read ↗

Structure and Function of the Proteins of the Mammalian Zona pellucidaSemantic proximity Read ↗

Cracking the egg: increased complexity in the zona pellucidaSemantic proximity Read ↗

Phylogenetic Analysis and Identification of Pseudogenes Reveal a Progressive Loss of Zona Pellucida Genes During Evolution of Vertebrates1Semantic proximity Read ↗

Mutations in ZP4 are associated with abnormal zona pellucida and female infertility.Semantic proximity Read ↗

Three‐dimensional structure of the zona pellucida at ovulationSemantic proximity Read ↗

Three-dimensional structure of the zona pellucidaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.