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Article

Molecular characterisation of ILRUN, a novel inhibitor of proinflammatory and antimicrobial cytokines

1 Jun 2020

Abstract excerpt

Regulation of type-I interferon (IFN) production is essential to the balance between antimicrobial defence and autoimmune disorders. The human protein-coding gene ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains, previously C6orf106) was recently characterised as an inhibitor of antiviral and proinflammatory cytokine (interferon-alpha/beta and tumor necrosis factor alpha) transcription....

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PMID: 32518853
DOI: 10.1016/j.heliyon.2020.e04115

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