Article
Identifying the role of PrimPol in TDF-induced toxicity and implications of its loss of function mutation in an HIV+ patient.
Scientific reports - 9 Jun 2020
Duong Vincent N, Zhou Lei, Martínez-Jiménez María I, He Linh, Cosme Moises, Blanco Luis, Paintsil Elijah, Anderson Karen S
Abstract excerpt
A key component of antiretroviral therapy (ART) for HIV patients is the nucleoside reverse transcriptase inhibitor (NRTI) is tenofovir. Recent reports of tenofovir toxicity in patients taking ART for HIV cannot be explained solely on the basis of off-target inhibition of mitochondrial DNA polymerase gamma (Polγ). PrimPol was discovered as a primase-polymerase localized to the mitochondria with repriming and...
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