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Article

Off-Target Effects of Drugs that Disrupt Human Mitochondrial DNA Maintenance

22 Nov 2017

Abstract excerpt

Nucleoside reverse transcriptase inhibitors (NRTIs) were the first drugs used to treat human immunodeficiency virus (HIV) the cause of acquired immunodeficiency syndrome. Development of severe mitochondrial toxicity has been well documented in patients infected with HIV and administered NRTIs. In vitro biochemical experiments have demonstrated that the replicative mitochondrial DNA (mtDNA) polymerase gamma, Polg,...

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PMID: 29214156
DOI: 10.3389/fmolb.2017.00074

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