Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation of multinucleated giant cells by culture of monocyte-derived macrophages with IL-4.

Journal of leukocyte biology - 1 Apr 1997

Dugast C, Gaudin A, Toujas L

Abstract excerpt

Culturing human monocytes in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) has been reported to provoke the formation of multinucleated giant cells (GCs). In the present work, GCs were generated in a two-step procedure in which macrophages were first differentiated from monocytes before being fused into GCs. The two cytokines used acted sequentially. GM-CSF was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Surface
Share to Cell Differentiation
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-4

Share to Leukocytes, Mononuclear

Share to Macrophages

Share to Phagocytosis

Share to Phenotype

Source

Identifiers

PMID: 9103239
DOI: 10.1002/jlb.61.4.517

Genes

AMH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation of multinucleated giant cells by culture of monocyte-derived macrophages with IL-4.PMID 9103239Read ↗

Multinucleated giant cell phenotype in response to stimulation.Semantic proximity Read ↗

Monocyte–Macrophage Lineage Cell FusionSemantic proximity Read ↗

Macrophage fusion and multinucleated giant cells of inflammation.Semantic proximity Read ↗

Monocyte Subsets Have Distinct Patterns of Tetraspanin Expression and Different Capacities to Form Multinucleate Giant CellsSemantic proximity Read ↗

Macrophage polarization state influences fusion and phenotype of human foreign body giant cells in vitro.Semantic proximity Read ↗

Foreign body giant cell formation is preceded by lamellipodia formation and can be attenuated by inhibition of Rac1 activation.Semantic proximity Read ↗

Cellular and molecular actors of myeloid cell fusion: podosomes and tunneling nanotubes call the tuneSemantic proximity Read ↗

Essential Role of DAP12 Signaling in Macrophage Programming into a Fusion-Competent StateSemantic proximity Read ↗

Osteoclasts and giant cells: macrophage-macrophage fusion mechanism Current Status Review: Granulatomous DiseaseSemantic proximity Read ↗

Common signalling pathways in macrophage and osteoclast multinucleationSemantic proximity Read ↗

Multinucleation resets human macrophages for specialized functions at the expense of mononuclear phagocyte identitySemantic proximity Read ↗

Multinucleated giant cells with an osteoclast phenotype derived from caprine peripheral blood mononuclear cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.