Generation of multinucleated giant cells by culture of monocyte-derived macrophages with IL-4.

doi:10.1002/jlb.61.4.517

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Article

Generation of multinucleated giant cells by culture of monocyte-derived macrophages with IL-4.

Journal of leukocyte biology - 1 Apr 1997

Dugast C, Gaudin A, Toujas L

Abstract excerpt

Culturing human monocytes in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) has been reported to provoke the formation of multinucleated giant cells (GCs). In the present work, GCs were generated in a two-step procedure in which macrophages were...

Topics

Antigens, Surface
Cell Differentiation
Cells, Cultured
Giant Cells
Granulocyte-Macrophage Colony-Stimulating Factor
Humans
Interleukin-4
Leukocytes, Mononuclear
Macrophages
Phagocytosis
Phenotype

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