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Article

Foreign body giant cell formation is preceded by lamellipodia formation and can be attenuated by inhibition of Rac1 activation.

The American journal of pathology - 1 Aug 2007

Jay Steven M, Skokos Eleni, Laiwalla Farah, Krady Marie-Marthe, Kyriakides Themis R

Abstract excerpt

Macrophages that are recruited to the site of implanted biomaterials undergo fusion to form surface-damaging foreign body giant cells. Exposure of peripheral blood monocytes to interleukin-4 can recapitulate the fusion process in vitro. In this study, we used interleukin-4 to induce multinucleation of murine bone marrow-derived macrophages and observed changes in cell shape, including elongation and lamellipodia...

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Source

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Identifiers

PMID: 17556592
DOI: 10.2353/ajpath.2007.061213
PMCID: PMC1934537

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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