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SIRT2 suppresses expression of inflammatory factors via Hsp90‐glucocorticoid receptor signalling

9 Jun 2020

Abstract excerpt

-dependent deacetylase that deacetylates a diverse array of protein substrates and is involved in many cellular processes, including regulation of inflammation. However, its precise role in the inflammatory process has not completely been elucidated. Here, we identify heat-shock protein 90α (Hsp90α) as novel substrate of SIRT2. Functional investigation suggests that Hsp90 is deacetylated by SIRT2, such that...

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PMID: 32515550
DOI: 10.1111/jcmm.15365

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