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Article

Differential alteration of heat shock protein 90 in mice modifies glucocorticoid receptor function and susceptibility to trauma.

Journal of neurotrauma - 1 Feb 2010

Shen Hai-Ying, Zhao Yan, Chen Xing-Yun, Xiong Ren-Ping, Lu Jin-Li, Chen Jiang-Fan, Chen Li-Yong, Zhou Yuan-Guo

Abstract excerpt

Heat shock protein 90 (Hsp90), encoded by the murine hsp84 and hsp86 genes in mice, is a pivotal regulator of glucocorticoid receptor (GR) function in the hypothalamus-pituitary-adrenal axis and affords stress protection. To explore the underlying molecular mechanisms of strain susceptibility to traumatic stress, we investigated the alteration by Hsp90 of the function of the glucocorticoid-glucocorticoid receptor...

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Identifiers

PMID: 19845467
DOI: 10.1089/neu.2009.0926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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