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Article

A conformational switch in the ligand-binding domain regulates the dependence of the glucocorticoid receptor on Hsp90.

Journal of molecular biology - 4 May 2007

Ricketson D, Hostick U, Fang L, Yamamoto K R, Darimont B D

Abstract excerpt

Steroid hormone receptors (SRs) are transcription factors that act as regulatory switches by altering gene expression in response to ligands. The highly conserved ligand-binding domain of SRs is a precise but versatile molecular switch that can adopt distinct conformations. Differential stabilization of these conformations by ligands, DNA response elements and transcriptional coregulators controls the activity of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17367809
DOI: 10.1016/j.jmb.2007.02.057
PMCID: PMC2596751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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