A conformational switch in the ligand-binding domain regulates the dependence of the glucocorticoid receptor on Hsp90.

doi:10.1016/j.jmb.2007.02.057

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Article

A conformational switch in the ligand-binding domain regulates the dependence of the glucocorticoid receptor on Hsp90.

Journal of molecular biology - 4 May 2007

Ricketson D, Hostick U, Fang L, Yamamoto K R, Darimont B D

Abstract excerpt

Steroid hormone receptors (SRs) are transcription factors that act as regulatory switches by altering gene expression in response to ligands. The highly conserved ligand-binding domain of SRs is a precise but versatile molecular switch that can adopt distinct conformations. Differential stabilization of these conformations by ligands, DNA response elements and transcriptional coregulators controls the activity of...

Topics

Allosteric Regulation
Amino Acid Substitution
Animals
Binding Sites
Cell Nucleus
Cytoplasm
Dexamethasone
HSP90 Heat-Shock Proteins
Humans
Ligands
Models, Molecular
Mutation
Protein Conformation
Protein Structure, Tertiary

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Identifiers

PMID: 17367809
DOI: 10.1016/j.jmb.2007.02.057
PMCID: PMC2596751

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Rats

Receptors, Glucocorticoid

Saccharomyces cerevisiae