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Article

LncRNA ANRIL acts as a modular scaffold of WDR5 and HDAC3 complexes and promotes alteration of the vascular smooth muscle cell phenotype.

Cell death & disease - 8 Jun 2020

Zhang Chengxin, Ge Shangqing, Gong Wenhui, Xu Jinguo, Guo Zhixiang, Liu Zhuang, Gao Xiaotian, Wei Xiaoyong, Ge Shenglin

Abstract excerpt

Many studies have shown that long-noncoding RNA (lncRNA) is associated with cardiovascular disease, but its molecular mechanism is still unclear. In this study, we explored the role of lncRNA ANRIL in ox-LDL-induced phenotypic transition of human aortic smooth muscle cells (HASMC). The results of quantitative fluorescence PCR showed that the expression of ANRIL in patients with coronary atherosclerotic heart...

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Source

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Identifiers

PMID: 32513988
DOI: 10.1038/s41419-020-2645-3
PMCID: PMC7280314

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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