Article
ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2011
Pasmant Eric, Sabbagh Audrey, Vidaud Michel, Bièche Ivan
Abstract excerpt
A large noncoding RNA called ANRIL (for antisense noncoding RNA in the INK4 locus) has been identified within the p15/CDKN2B-p16/CDKN2A-p14/ARF gene cluster. While the exact role of ANRIL awaited further elucidation, common disease genomewide association studies (GWAS) have surprisingly identified the ANRIL gene as a genetic susceptibility locus shared associated by coronary disease, intracranial aneurysm and...
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