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Article

ANRIL: molecular mechanisms and implications in human health.

International journal of molecular sciences - 10 Jan 2013

Congrains Ada, Kamide Kei, Ohishi Mitsuru, Rakugi Hiromi

Abstract excerpt

ANRIL is a recently discovered long non-coding RNA encoded in the chromosome 9p21 region. This locus is a hotspot for disease-associated polymorphisms, and it has been consistently associated with cardiovascular disease, and more recently with several cancers, diabetes, glaucoma, endometriosis among other conditions. ANRIL has been shown to regulate its neighbor tumor suppressors CDKN2A/B by epigenetic mechanisms...

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Identifiers

PMID: 23306151
DOI: 10.3390/ijms14011278
PMCID: PMC3565320

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