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Article

AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic malformation.

Angiogenesis - 1 Apr 2015

Boscolo Elisa, Coma Silvia, Luks Valerie L, Greene Arin K, Klagsbrun Michael, Warman Matthew L, Bischoff Joyce

Abstract excerpt

Lymphatic malformations (LM) are characterized by abnormal formation of lymphatic vessels and tissue overgrowth. The lymphatic vessels present in LM lesions may become blocked and enlarged as lymphatic fluid collects, forming a mass or cyst. Lesions are typically diagnosed during childhood and are often disfiguring and life threatening. Available treatments consist of sclerotherapy, surgical removal and therapies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phosphatidylinositol 3-Kinases

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Share to Proto-Oncogene Proteins c-akt

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Share to Vascular Malformations and Hemangiomas

Source

Open in PubMed Open full text

Identifiers

PMID: 25424831
DOI: 10.1007/s10456-014-9453-2
PMCID: PMC4366356

Genes

LYVE1
PROX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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