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Article

PIK3CA mutations are specifically localized to lymphatic endothelial cells of lymphatic malformations.

PloS one - 1 Jan 2018

Blesinger Hannah, Kaulfuß Silke, Aung Thiha, Schwoch Sonja, Prantl Lukas, Rößler Jochen, Wilting Jörg, Becker Jürgen

Abstract excerpt

Lymphatic malformations (LM) are characterized by the overgrowth of lymphatic vessels during pre- and postnatal development. Macrocystic, microcystic and combined forms of LM are known. The cysts are lined by lymphatic endothelial cells (LECs). Resection and sclerotherapy are the most common treatment methods. Recent studies performed on LM specimens in the United States of America have identified activating...

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Share to Class I Phosphatidylinositol 3-Kinases
Share to Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Inhibitors

Share to Extracellular Signal-Regulated MAP Kinases

Share to Fibroblasts

Share to Lymphatic Vessels

Share to Proto-Oncogene Proteins c-akt

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 29985963
DOI: 10.1371/journal.pone.0200343
PMCID: PMC6037383

Genes

GAA

Variants

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