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Article

Lys694Arg polymorphism leads to blunted responses to LPS by interfering TLR4 with recruitment of MyD88.

Innate immunity - 1 Aug 2021

Yang Yajie, Hu Yan, Zhou Yile, Liang Tao, Tang Haihong, Ju Huihui, Shi Qiqing, Fang Hao

Abstract excerpt

TLR4 polymorphisms such as Asp299Gly and Thr399Ile related to Gram-negative sepsis have been reported to result in significantly blunted responsiveness to LPS. Our study group previously screened other TLR4 polymorphic variants by checking the NF-κB activation in comparison to wild type (WT) TLR4 in human embryonic kidney 293T cells. In this study, we found that the Lys694Arg (K694R) polymorphism reduced the...

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Identifiers

PMID: 32513051
DOI: 10.1177/1753425920927479
PMCID: PMC8504268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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