Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased NFk-B activity in HCT116 colorectal cancer cell line harboring TLR4 Asp299Gly variant.

Iranian journal of allergy, asthma, and immunology - 1 Jun 2012

Davoodi Homa, Hashemi Seyed Reza, Seow Heng Fong

Abstract excerpt

Toll-Like Receptor 4 (TLR4), considered one of the most important TLR, recognizes lipopolysaccharide of Gram-negative bacteria. Recognition of ligands by TLRs induces signaling pathways resulting in activation of transcriptional factors such as NF-κB which are involved in the expression of inflam...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspartic Acid
Share to Glycine
Share to HCT116 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to I-kappa B Proteins

Share to Interleukin-1 Receptor-Associated Kinases

Share to Luciferases

Share to Mitogen-Activated Protein Kinase 3

Share to Toll-Like Receptor 4

Source

Identifiers

PMID: 22761186
DOI: 011.02/ijaai.121132

Genes

TLR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22761186-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased NFk-B activity in HCT116 colorectal cancer cell line harboring TLR4 Asp299Gly variant.PMID 22761186Read ↗

Expression and Polymorphism of Toll-Like Receptor 4 and Effect on NF-κB Mediated Inflammation in Colon Cancer PatientsSemantic proximity Read ↗

Adenomatous polyposis coli genotype-dependent toll-like receptor 4 activity in colon cancer.Semantic proximity Read ↗

Impact of Toll-like receptor 4 polymorphisms on risk of cancer.Semantic proximity Read ↗

Toll-Like Receptors (TLRs): Structure, Functions, Signaling, and Role of Their Polymorphisms in Colorectal Cancer Susceptibility.Semantic proximity Read ↗

Functional polymorphisms of Toll-like receptors 2 and 4 alter the risk for colorectal carcinoma in Europeans.Semantic proximity Read ↗

Positive link between variant Toll-like receptor 4 (Asp299Gly and Thr399Ile) and colorectal cancer patients with advanced stage and lymph node metastasis.Semantic proximity Read ↗

Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in cancer: a meta-analysis.Semantic proximity Read ↗

The TLR4 D299G and T399I SNPs are constitutively active to up-regulate expression of Trif-dependent genes.Semantic proximity Read ↗

Genetic association and functional implications of TLR4 rs1927914 polymorphism on colon cancer risk.Semantic proximity Read ↗

TLR4 D299G polymorphism modulates cytokine expression in ulcerative colitis.Semantic proximity Read ↗

Contribution of TLR signaling to the pathogenesis of colitis-associated cancer in inflammatory bowel diseaseSemantic proximity Read ↗

An updated systematic review of the association between the TLR4 polymorphism rs4986790 and cancers risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.