Article
The Effect of Sodium Bicarbonate, a Beneficial Adjuvant Molecule in Cystic Fibrosis, on Bronchial Epithelial Cells Expressing a Wild-Type or Mutant CFTR Channel.
International journal of molecular sciences - 4 Jun 2020
Gróf Ilona, Bocsik Alexandra, Harazin András, Santa-Maria Ana Raquel, Vizsnyiczai Gaszton, Barna Lilla, Kiss Lóránd, Fűr Gabriella, Rakonczay Zoltán, Ambrus Rita, Szabó-Révész Piroska, Gosselet Fabien, Jaikumpun Pongsiri, Szabó Hajnalka, Zsembery Ákos, Deli Mária A
Abstract excerpt
Clinical and experimental results with inhaled sodium bicarbonate as an adjuvant therapy in cystic fibrosis (CF) are promising due to its mucolytic and bacteriostatic properties, but its direct effect has not been studied on respiratory epithelial cells. Our aim was to establish and characterize co-culture models of human CF bronchial epithelial (CFBE) cell lines expressing a wild-type (WT) or mutant (deltaF508)...
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