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High ionic strength vector formulations enhance gene transfer to airway epithelia

9 Jul 2024

Abstract excerpt

A fundamental challenge for cystic fibrosis (CF) gene therapy is ensuring sufficient transduction of airway epithelia to achieve therapeutic correction. Hypertonic saline (HTS) is frequently administered to people with CF to enhance mucus clearance. HTS transiently disrupts epithelial cell tight junctions, but its ability to improve gene transfer has not been investigated. Here, we asked if increasing the...

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PMID: 39077931
DOI: 10.1093/nar/gkae640

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