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Article

Brushed nasal epithelial cells are a surrogate for bronchial epithelial CFTR studies.

JCI insight - 12 Jul 2018

Brewington John J, Filbrandt Erin T, LaRosa F J, Moncivaiz Jessica D, Ostmann Alicia J, Strecker Lauren M, Clancy John P

Abstract excerpt

Recent advances in the management of cystic fibrosis (CF) target underlying defects in the CF transmembrane conductance regulator (CFTR) protein, but efficacy analyses remain limited to specific genotype-based subgroups. Patient-derived model systems may therefore aid in expanding access to these drugs. Brushed human nasal epithelial cells (HNEs) are an attractive tissue source, but it remains unclear how...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29997283
DOI: 10.1172/jci.insight.99385
PMCID: PMC6124537

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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