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Machine learning-based genome-wide interrogation of somatic copy number aberrations in circulating tumor DNA for early detection of hepatocellular carcinoma

1 Jun 2020

Abstract excerpt

BACKGROUND: DNAs released from tumor cells into blood (circulating tumor DNAs, ctDNAs) carry tumor-specific genomic aberrations, providing a non-invasive means for cancer detection. In this study, we aimed to leverage somatic copy number aberration (SCNA) in ctDNA to develop assays to detect early-stage HCCs. METHODS: We conducted low-depth whole-genome sequencing (WGS) to profile SCNAs in 384 plasma samples of...

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Share to Cancer Genomics and Diagnostics
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PMID: 32512514
DOI: 10.1016/j.ebiom.2020.102811

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