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Article

Prognostic value of ultra-low-pass whole-genome sequencing of circulating tumor DNA in hepatocellular carcinoma under systemic treatment.

Clinical and molecular hepatology - 1 Apr 2024

Sogbe Miguel, Bilbao Idoia, Marchese Francesco P, Zazpe Jon, De Vito Annarosaria, Pozuelo Marta, D'Avola Delia, Iñarrairaegui Mercedes, Berasain Carmen, Arechederra Maria, Argemi Josepmaria, Sangro Bruno

Abstract excerpt

BACKGROUND/AIMS: New prognostic markers are needed to identify patients with hepatocellular carcinoma (HCC) who carry a worse prognosis. Ultra-low-pass whole-genome sequencing (ULP-WGS) (≤0.5× coverage) of cell-free DNA (cfDNA) has emerged as a low-cost promising tool to assess both circulating tumor DNA (ctDNA) fraction and large structural genomic alterations. Here, we studied the performance of ULP-WGS of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38163441
DOI: 10.3350/cmh.2023.0426
PMCID: PMC11016491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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