Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ultrasensitive and affordable assay for early detection of primary liver cancer using plasma cell‐free DNA fragmentomics

26 Dec 2021

Abstract excerpt

BACKGROUND AND AIMS: Early detection of primary liver cancer (PLC), including HCC, intrahepatic cholangiocarcinoma (ICC), and combined HCC-ICC (cHCC-ICC), is essential for patients' survival. This study aims to develop an accurate and affordable method for PLC early detection and differentiating ICC from HCC using plasma cell-free DNA (cfDNA) fragmentomic profiles. APPROACH AND RESULTS: Whole-genome sequencings...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Cholangiocarcinoma and Gallbladder Cancer Studies
Share to Hepatocellular Carcinoma Treatment and Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34954829
DOI: 10.1002/hep.32308

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ultrasensitive and affordable assay for early detection of primary liver cancer using plasma cell‐free DNA fragmentomicsPMID 34954829Read ↗

Noninvasive, Accurate Diagnosis of Chronic Liver Diseases Using Whole-Transcriptome Profiling of PlateletsSemantic proximity Read ↗

Early detection and stratification of colorectal cancer using plasma cell-free DNA fragmentomic profilingSemantic proximity Read ↗

Aberrant fragmentomic features of circulating cell-free mitochondrial DNA enable early detection and prognosis prediction of hepatocellular carcinomaSemantic proximity Read ↗

Screening of Hepatocellular Carcinoma in Hepatic Cirrhosis Patients by a Novel Blood-Based Multi-Omics Test.Semantic proximity Read ↗

Ultra-low coverage fragmentomic model of cell-free DNA for cancer detection based on whole-exome regionsSemantic proximity Read ↗

Development and Validation of a Cell-Free DNA Fragmentomics–Based Model for Early Detection of Pancreatic CancerSemantic proximity Read ↗

Machine learning-enabled early detection of hepatocellular carcinoma utilizing cell-free DNA mutation and fragmentation multiplicity: a prospective studySemantic proximity Read ↗

Novel, high accuracy models for hepatocellular carcinoma prediction based on longitudinal data and cell-free DNA signaturesSemantic proximity Read ↗

A Proposed AI/ML-Based Detection Framework for Early Detection of Hepatocellular Carcinoma (HCC) and CirrhosisSemantic proximity Read ↗

Fragment length profiles of cancer mutations enhance detection of circulating tumor DNA in patients with early-stage hepatocellular carcinoma.Semantic proximity Read ↗

DNA methylation biomarkers for diagnosis of primary liver cancer and distinguishing hepatocellular carcinoma from intrahepatic cholangiocarcinomaSemantic proximity Read ↗

Enrichment of short mutant cell-free DNA fragments enhanced detection of pancreatic cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.