Role of Rare and Low-Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels.

doi:10.1161/CIRCGEN.119.002772

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Article

Role of Rare and Low-Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels.

Circulation. Genomic and precision medicine - 1 Aug 2020

Wang Zhe, Chen Han, Bartz Traci M, Bielak Lawrence F, Chasman Daniel I, Feitosa Mary F, Franceschini Nora, Guo Xiuqing, Lim Elise, Noordam Raymond, Richard Melissa A, Wang Heming, Cade Brian, Cupples L Adrienne, de Vries Paul S, Giulanini Franco, Lee Jiwon, Lemaitre Rozenn N, Martin Lisa W, Reiner Alex P, Rich Stephen S, Schreiner Pamela J, Sidney Stephen, Sitlani Colleen M, Smith Jennifer A, Willems van Dijk Ko, Yao Jie, Zhao Wei, Fornage Myriam, Kardia Sharon L R, Kooperberg Charles, Liu Ching-Ti, Mook-Kanamori Dennis O, Province Michael A, Psaty Bruce M, Redline Susan, Ridker Paul M, Rotter Jerome I, Boerwinkle Eric, Morrison Alanna C

Abstract excerpt

BACKGROUND: Alcohol intake influences plasma lipid levels, and such effects may be moderated by genetic variants. We aimed to characterize the role of aggregated rare and low-frequency protein-coding variants in gene by alcohol consumption interactions associated with fasting plasma lipid levels. METHODS: In the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, fasting plasma triglycerides...

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PMID: 32510982
DOI: 10.1161/CIRCGEN.119.002772
PMCID: PMC7442680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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