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Article

The genetic architecture of the familial hyperlipidaemia syndromes: rare mutations and common variants in multiple genes.

Current opinion in lipidology - 1 Aug 2014

Talmud Philippa J, Futema Marta, Humphries Steve E

Abstract excerpt

PURPOSE OF REVIEW: Genome-Wide Association Studies have provided robust identification of approximately 100 genetic loci determining plasma lipid parameters. Using these multiple common genetic lipid-determining variants in a 'gene score' has thrown new light on the mode of inheritance of familial lipid disorders. RECENT FINDINGS: Different hypertriglyceridaemia states have been explained by the polygenic...

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Identifiers

PMID: 24977977
DOI: 10.1097/MOL.0000000000000090

Genes

PCSK9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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