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Intergenerationally Maintained Histone H4 Lysine 16 Acetylation Is Instructive for Future Gene Activation.

Cell - 9 Jul 2020

Samata Maria, Alexiadis Anastasios, Richard Gautier, Georgiev Plamen, Nuebler Johannes, Kulkarni Tanvi, Renschler Gina, Basilicata M Felicia, Zenk Fides Lea, Shvedunova Maria, Semplicio Giuseppe, Mirny Leonid, Iovino Nicola, Akhtar Asifa

Abstract excerpt

Before zygotic genome activation (ZGA), the quiescent genome undergoes reprogramming to transition into the transcriptionally active state. However, the mechanisms underlying euchromatin establishment during early embryogenesis remain poorly understood. Here, we show that histone H4 lysine 16 acetylation (H4K16ac) is maintained from oocytes to fertilized embryos in Drosophila and mammals. H4K16ac forms large...

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PMID: 32502394
DOI: 10.1016/j.cell.2020.05.026

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