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Article

FSTL1 sustains glioma stem cell stemness and promotes immunosuppressive macrophage polarization in glioblastoma.

Cancer letters - 28 Feb 2025

Zhou Fengqi, Tao Jincheng, Gou Huiqing, Liu Shuheng, Yu Dong, Zhang Junxia, Ji Jianxiong, Lin Ning, Wang Yingyi

Abstract excerpt

Tumor-associated macrophages (TAMs) within the tumor microenvironment (TME) play a crucial role in glioblastoma (GBM) progression by interacting with glioma stem cells (GSCs). These interactions lead to the polarization of TAMs toward an M2 phenotype, which, in turn, enhances the stem-like traits and malignant progression of GSCs. Our study shows that FSTL1, a protein released by GSCs, is significantly elevated...

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Source

Identifiers

PMID: 39722404
DOI: 10.1016/j.canlet.2024.217400

Genes

FSTL1
TLR2
EGFR
GSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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