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DNA damage in preimplantation embryos and gametes: specification, clinical relevance and repair strategies

15 Dec 2021

Abstract excerpt

BACKGROUND: DNA damage is a hazard that affects all cells of the body. DNA-damage repair (DDR) mechanisms are in place to repair damage and restore cellular function, as are other damage-induced processes such as apoptosis, autophagy and senescence. The resilience of germ cells and embryos in response to DNA damage is less well studied compared with other cell types. Given that recent studies have described links...

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PMID: 35021196
DOI: 10.1093/humupd/dmab046

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