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Article

Genetic analysis of circulating metabolic traits in 619,372 individuals.

Nature - 1 Jul 2026

Tambets Ralf, Jesse Mihkel, Kronberg Jaanika, van der Graaf Adriaan, Abner Erik, Võsa Urmo, Rahu Ida, Taba Nele, Kolde Anastassia, Yarish Dzvenymyra, Abdullayeva Sariyya, Alekseienko Anastasiia, Veidenberg Andres, Fischer Krista, Kutalik Zoltán, Esko Tõnu, Alasoo Kaur, Palta Priit

Abstract excerpt

Interpreting the association of genetic variants with complex traits can be improved by gaining a greater understanding of the molecular consequences of these variants. Although genome-wide association studies (GWAS) for complex diseases routinely profile over one million individuals1-5, studies of molecular traits have lagged behind. Here we performed a GWAS meta-analysis for 249 circulating metabolic traits in...

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Identifiers

PMID: 42162431
DOI: 10.1038/s41586-026-10532-5
PMCID: PMC13391353

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