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Article

The Bayesian lasso for genome-wide association studies.

Bioinformatics (Oxford, England) - 15 Feb 2011

Li Jiahan, Das Kiranmoy, Fu Guifang, Li Runze, Wu Rongling

Abstract excerpt

MOTIVATION: Despite their success in identifying genes that affect complex disease or traits, current genome-wide association studies (GWASs) based on a single SNP analysis are too simple to elucidate a comprehensive picture of the genetic architecture of phenotypes. A simultaneous analysis of a large number of SNPs, although statistically challenging, especially with a small number of samples, is crucial for...

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PMID: 21156729
DOI: 10.1093/bioinformatics/btq688
PMCID: PMC3105480

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