Article
Logistic Bayesian LASSO for identifying association with rare haplotypes and application to age-related macular degeneration.
Biometrics - 1 Jun 2012
Biswas Swati, Lin Shili
Abstract excerpt
Rare variants have been heralded as key to uncovering "missing heritability" in complex diseases. These variants can now be genotyped using next-generation sequencing technologies; nonetheless, rare haplotypes may also result from combination of common single nucleotide polymorphisms available from genome-wide association studies (GWAS). The National Eye Institute's data on age-related macular degeneration (AMD)...
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