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Article

Fluctuation Imaging of LRRK2 Reveals that the G2019S Mutation Alters Spatial and Membrane Dynamics.

Molecules (Basel, Switzerland) - 31 May 2020

Sanstrum Bethany J, Goo Brandee M S S, Holden Diana Z Y, Delgado Donovan D, Nguyen Thien P N, Lee Kiana D, James Nicholas G

Abstract excerpt

Mutations within the Leucine-Rich Repeat Kinase 2 (LRRK2) gene are the most common genetic cause of autosomal and sporadic Parkinson's disease (PD). LRRK2 is a large multidomain kinase that has reported interactions with several membrane proteins, including Rab and Endophilin, and has recently been proposed to function as a regulator of vesicular trafficking. It is unclear whether or how the spatiotemporal...

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PMID: 32486414
DOI: 10.3390/molecules25112561
PMCID: PMC7321188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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