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Article

Investigation of CFTR Function in Human Nasal Epithelial Cells Informs Personalized Medicine.

American journal of respiratory cell and molecular biology - 1 Nov 2024

Pion Audrey, Kavanagh Erin, Joynt Anya T, Raraigh Karen S, Vanscoy Lori, Langfelder-Schwind Elinor, McNamara John, Moore Brooke, Patel Shivani, Merlo Kate, Temme Renee, Capurro Valeria, Pesce Emanuela, Merlo Christian, Pedemonte Nicoletta, Cutting Garry R, Sharma Neeraj

Abstract excerpt

We broaden the clinical versatility of human nasal epithelial (HNE) cells. HNEs were isolated from 10 participants harboring cystic fibrosis transmembrane conductance regulator (CFTR) variants: 9 with rare variants (Q359R [n=2], G480S, R334W [n=5], and R560T) and 1 harboring R117H;7T;TG10/5T;TG12. Cultures were differentiated at the air-liquid interface. CFTR function was measured in Ussing chambers at three...

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PMID: 39012815
DOI: 10.1165/rcmb.2023-0398OC
PMCID: PMC11568479

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CFTR

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