Article
[Characterization of genetic alterations in primary human melanomas carrying BRAF or NRAS mutation].
Magyar onkologia - 1 Jun 2013
Lázár Viktória
Abstract excerpt
Human malignant melanoma is one of the most aggressive forms of skin cancer with an exceptionally bad prognosis. Melanoma often displays constitutively activated MAPK pathway through BRAF or NRAS mutations. It is also known that these mutations are almost never simultaneously present and that they appear at early stages and preserved throughout tumor progression, although it is proved that these alterations alone...
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