Marked genetic differences between BRAF and NRAS mutated primary melanomas as revealed by array comparative genomic hybridization.

doi:10.1097/CMR.0b013e328352dbc8

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Article

Marked genetic differences between BRAF and NRAS mutated primary melanomas as revealed by array comparative genomic hybridization.

Melanoma research - 1 Jun 2012

Lázár Viktória, Ecsedi Szilvia, Vízkeleti Laura, Rákosy Zsuzsa, Boross Gábor, Szappanos Balázs, Bégány Agnes, Emri Gabriella, Adány Róza, Balázs Margit

Abstract excerpt

Somatic mutations of BRAF and NRAS oncogenes are thought to be among the first steps in melanoma initiation, but these mutations alone are insufficient to cause tumor progression. Our group studied the distinct genomic imbalances of primary melanomas harboring different BRAF or NRAS genotypes. We also aimed to highlight regions of change commonly seen together in different melanoma subgroups. Array comparative...

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Identifiers

PMID: 22456166
DOI: 10.1097/CMR.0b013e328352dbc8

Genes

BRAF
NRAS
EGF

Provenance

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