Article

Endometrial epithelial ARID1A is critical for uterine gland function in early pregnancy establishment

2020-09-24

Abstract excerpt

Though endometriosis and infertility are clearly associated, the pathophysiological mechanism remains unclear. Previous work has linked endometrial ARID1A loss to endometriosis-related endometrial non-receptivity. Here, we show in mice that ARID1A binds and regulates transcription of the Foxa2 gene required for endometrial gland function. Uterine specific deletion of Arid1a compromises gland development and dimi...

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Literature Corpus work: cea86a7b-bf04-5299-a725-504e6b8ee494
DOI: 10.1101/2020.09.23.308528

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