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Article

ARID1A loss activates MAPK signaling via DUSP4 downregulation

9 Dec 2023

Abstract excerpt

BACKGROUND: ARID1A, a tumor suppressor gene encoding BAF250, a protein participating in chromatin remodeling, is frequently mutated in endometrium-related malignancies, including ovarian or uterine clear cell carcinoma (CCC) and endometrioid carcinoma (EMCA). However, how ARID1A mutations alter downstream signaling to promote tumor development is yet to be established. METHODS: We used RNA-sequencing (RNA-seq) to...

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PMID: 38071325
DOI: 10.1186/s12929-023-00985-5

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ARID1A loss activates MAPK signaling via DUSP4 downregulationPMID 38071325Read ↗

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