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Article

ARID1A: gene, protein, and function in endometrial cancer.

Oncogene - 1 Sept 2025

LaBuda Savannah E, Broaddus Russell R, Gladden Andrew B

Abstract excerpt

ARID1A, a key structural subunit of the SWI/SNF chromatin remodeling complex, is the most frequently mutated SWI/SNF subunit in cancer with most mutations occurring in endometrial cancer. In a multitude of malignancies, loss of ARID1A protein correlates with poor patient prognosis, increased metastasis, and changes to key cancer pathways such as genomic instability. Despite this, little work has been done to...

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Source

Identifiers

PMID: 40826172
DOI: 10.1038/s41388-025-03539-1

Genes

ARID1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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ARID1A: gene, protein, and function in endometrial cancer.PMID 40826172Read ↗

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Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming.Semantic proximity Read ↗

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